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Surface-tension-induced budding drives alveologenesis in human mammary gland organoids

The development of glands involves cylindrical branches transforming into spherical alveoli. Now there is evidence to suggest that this process can be understood as a budding instability driven by a decrease in tension anisotropy in the tissue.

Organ development involves complex shape transformations driven by active mechanical stresses that sculpt the growing tissue(1,2). Epithelial gland morphogenesis is a prominent example where cylindrical branches transform into spherical alveoli during growth(3-5). Here we show that this shape transformation is induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids. By combining laser ablation with optical force inference and theoretical analysis, we demonstrate that circumferential tension increases at the expense of axial tension through a reorientation of cells that correlates with the onset of persistent collective rotation around the branch axis. This enables the tissue to locally control the onset of a generalized Rayleigh-Plateau instability, leading to spherical tissue buds(6). The interplay between cell motion, cell orientation and tissue tension is a generic principle that may turn out to drive shape transformations in other cell tissues.


Research Cooperation

CeNS stimulates and supports research cooperation - crossing the borders between disciplines and different institutions. Shared knowledge and know-how as well as continuous discussions between the members of the network promote synergy effects which boost scientific progress. CeNS continuously provides a multitude of different occasions for the researchers to meet and exchange ideas during scientific meetings and social events. Furthermore, the scientific board awards funding for cooperation projects of scientists belonging to different CeNS groups.

The successful collaborative research work between different CeNS scientists from Physics, Chemistry, Biology, Pharmacy and Medicine leads to joint research papers published in high-impact journals. The following list shows a selection of recently published cooperative papers:

A diffusiophoretic mechanism for ATP-driven transport without motor proteins

B. Ramm, A. Goychuk, A. Khmelinskaia, P. Blumhardt, H. Eto, K. A. Ganzinger, E. Frey and P. Schwille: Nature Physics, 10.1038/s41567-021-01213-3 (2021) more …

Increasing Photostability of Inverted Nonfullerene Organic Solar Cells by Using Fullerene Derivative Additives

Marcella Guenther, Dominic Blaette, Anna Lena Oechsle, Sergio Sanchez Rivas, Amir Abbas Yousefi Amin, Peter Muller-Buschbaum, Thomas Bein, Tayebeh Ameri


 more …

Graphene-on-Glass Preparation and Cleaning Methods Characterized by Single-Molecule DNA Origami Fluorescent Probes and Raman Spectroscopy

Stefan Krause, Evelyn Ploetz, Johann Bohlen, Patrick Schuler, Renukka Yaadav, Florian Selbach, Florian Steiner, Izabela Kaminska, Philip Tinnefeld

10.1021/acsnano.0c08383 more …

Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids

B. Illes, A. Fuchs, F. Gegenfurtner, E. Ploetz, S. Zahler, A. M. Vollmar and H. Engelke: Iscience, 10.1016/j.isci.2021.102185 (2021) ://WOS:000631646000058 more …

Ionothermal Synthesis of Imide-Linked Covalent Organic Frameworks

J. Maschita, T. Banerjee, G. Savasci, F. Haase, C. Ochsenfeld and B. V. Lotsch: - Angewandte Chemie-International Edition, 10.1002/anie.202007372 (2020)  more …

Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles

L. Haddick, W. Zhang, S. Reinhard, K. Moller, H. Engelke, E. Wagner and T. Bein: - Pharmaceutics, 10.3390/pharmaceutics12060505 (2020)  more …

Dynamics of the Buckling Transition in Double-Stranded DNA and RNA

Katharina Ott, Linda Martini, Jan Lipfert, Ulrich Gerland: - doi.org/10.1016/j.bpj.2020.01.049 more …

Locally-triggered hydrophobic collapse induces global interface self-cleaning in van-der-Waals heterostructures at room-temperature

S. Wakolbinger, F. R. Geisenhof, F. Winterer, S. Palmer, J. G. Crimmann, K. Watanabe, T. Taniguchi, F. Trixler and R. T. Weitz: - 2d Materials, 10.1088/2053-1583/ab7bfc (2020)  more …

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

Ploetz E, Engelke H, Lachelt U, Wuttke S - Advanced Functional Materials. more …

Metal-Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

E. Ploetz, A. Zimpel, V. Cauda, D. Bauer, D. C. Lamb, C. Haisch, S. Zahler, A. M. Vollmar, S. Wuttke and H. Engelke: - Advanced Materials, 10.1002/adma.201907267 (2020)  more …

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