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Surface-tension-induced budding drives alveologenesis in human mammary gland organoids

The development of glands involves cylindrical branches transforming into spherical alveoli. Now there is evidence to suggest that this process can be understood as a budding instability driven by a decrease in tension anisotropy in the tissue.

Organ development involves complex shape transformations driven by active mechanical stresses that sculpt the growing tissue(1,2). Epithelial gland morphogenesis is a prominent example where cylindrical branches transform into spherical alveoli during growth(3-5). Here we show that this shape transformation is induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids. By combining laser ablation with optical force inference and theoretical analysis, we demonstrate that circumferential tension increases at the expense of axial tension through a reorientation of cells that correlates with the onset of persistent collective rotation around the branch axis. This enables the tissue to locally control the onset of a generalized Rayleigh-Plateau instability, leading to spherical tissue buds(6). The interplay between cell motion, cell orientation and tissue tension is a generic principle that may turn out to drive shape transformations in other cell tissues.

https://www.webofscience.com/wos/woscc/full-record/WOS:000705937300027

Research Cooperation

CeNS stimulates and supports research cooperation - crossing the borders between disciplines and different institutions. Shared knowledge and know-how as well as continuous discussions between the members of the network promote synergy effects which boost scientific progress. CeNS continuously provides a multitude of different occasions for the researchers to meet and exchange ideas during scientific meetings and social events. Furthermore, the scientific board awards funding for cooperation projects of scientists belonging to different CeNS groups.

The successful collaborative research work between different CeNS scientists from Physics, Chemistry, Biology, Pharmacy and Medicine leads to joint research papers published in high-impact journals. The following list shows a selection of recently published cooperative papers:

Reconstitution reveals how myosin-VI self-organises to generate a dynamic mechanism of membrane sculpting

Benoit Rogez, Laeschkir Würthner, Anastasiia B. Petrova, Felix B. Zierhut, Dario Saczko-Brack, Maria-Ana Huergo, Christopher Batters, Erwin Frey & Claudia Veigel - Nature Communications, doi.org/10.1038/s41467-019-11268-9 (2019) more …

Polymer Nanoreactors Shield Perovskite Nanocrystals from Degradation

Hintermayr, Verena A.; Lampe, Carola; Loew, Maximilian; Roemer, Janina; Vanderlinden, Willem; Gramlich, Moritz; Boehm, Anton X.; Sattler, Cornelia; Nickel, Bert; Lohmueller, Theobald; Urban, Alexander S - Nano Letters, doi.org/10.1021/acs.nanolett.9b00982 (2019) more …

Sustained Solar H-2 Evolution from a Thiazolo[5,4-d]thiazole-Bridged Covalent Organic Framework and Nickel-Thiolate Cluster in Water

Biswal, BP; Vignolo-Gonzalez, HA; Banerjee, T; Grunenberg, L; Savasci, G; Gottschling, K; Nuss, J; Ochsenfeld, C; Lotsch, BV - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, doi.org/10.1021/jacs.9b03243 (2019) more …

Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns

Fink A, Bruckner DB, Schreiber C, Rottgermann PJF, Broedersz CP, Radler JO - Biophysical Journal 2020, 118:552-564. more …

Density fluctuations as door-opener for diffusion on crowded surfaces

A.-K. Henß, S. Sakong, P.K. Messer, J. Wiechers, R. Schuster, D.C. Lamb, A. Groß, and J. Wintterlin - Science, DOI: 10.1126/science.aav4143 (2019) more …

DNA-Mediated Self-Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot

Francesca Nicoli, Tao Zhang, Kristina Hübner, Boyuan Jin, Florian Selbach, Guillermo Acuna, Christos Argyropoulos, Tim Liedl, Mauricio Pilo‐Pais - Small, doi.org/10.1002/smll.201804418 (2019) more …

H-2 Evolution with Covalent Organic Framework Photocatalysts

T. Banerjee, K. Gottschling, G. Savasci, C. Ochsenfeld and B. V. Lotsch - Acs Energy Letters, 10.1021/acs.energy.lett.7b01123 (2018) more …

Tracking the Source of Carbon Dot Photoluminescence: Aromatic Domains versus Molecular

F. Ehrat, S. Bhattacharyya, J. Schneider, A. Lof, R. Wyrwich, A. L. Rogach, J. K. Stolarczyk, A. S. Urban and J. Feldmann - Nano Letters, 10.1021/acs.nanolett.7b03863 (2017) more …

Single-Site Photocatalytic H2 Evolution from Covalent Organic Frameworks with Molecular Cobaloxime Co-Catalysts

T. Banerjee, F. Haase, G. Savasci, K. Gottschling, C. Ochsenfeld and B. V. Lotsch - Journal of the American Chemical Society, 10.1021/jacs.7b07489 (2017)  more …

Nonagglomerated Iron Oxyhydroxide Akaganeite Nanocrystals Incorporating Extraordinary High Amounts of Different Dopants

K. Fominykh, D. Bohm, S. Y. Zhang, A. Folger, M. Doblinger, T. Bein, C. Scheu and D. Fattakhova-Rohlfing - Chemistry of Materials, 10.1021/acs.chemmater.7b01611 (2017)  more …