Thursday, 28 August, 2008
Click Chemistry for High-Density Biofunctionalization of Mesoporous Silica
A. Schlossbauer, D. Schaffert, J. Kecht, E. Wagner, and T. Bein -
J. Am. Chem. Soc., 130 (38), 12558 (2008)
The applicability of click chemistry for high-density functionalization of mesoporous silica is demonstrated. The mild conditions of the copper(I)-catalyzed Huisgen reaction allow for a surface functionalization with intact biomolecules. The high covalent enzyme functionalization density under simultaneous retention of enzyme activity and the absence of leaching demonstrate the promising potential of this approach.