Wednesday, 12 June, 2013
Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles
S. Mackowiak , A. Schmidt , V. Weiss , C. Argyo , C. von Schirnding , T. Bein, and C. Bräuchle -
Nano Lett., Vol. 13 (6), pp. 2576-2583 (2013)
Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.