Wednesday, 20 January, 2010
Biophysicists reveal protein folding dynamics
Single-molecule, real-time measurements of a key biological process
Biophysicists at TUM, the Technische Universität München, have published the results of single-molecule experiments that bring a higher-resolution tool to the study of protein folding. How proteins arrive at the three-dimensional shapes that determine their essential functions or cause grave diseases when folding goes wrong is considered one of the most important and least understood questions in the biological and medical sciences. Folding itself follows a path determined by its energy landscape, a complex property described in unprecedented detail by the TUM researchers. In this week's issue of the Proceedings of the National Academy of Sciences (USA), they report taking hold of a single, zipper-like protein molecule and mapping changes in its energy landscape during folding and unfolding.
Press information TUM (english)
Press information TUM (deutsch)