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Thursday, 03 April, 2014

Effective 2D model does not account for geometry sensing by self-organized proteins patterns

J. Halatek, and E. Frey -
PNAS, doi: 10.1073/pnas.1220971111, published online: 3 April 2014

By means of a computational model analysisaccompanying intriguing experiments, Schweizer et al. (1) claim to show that MinE membrane binding is responsible for self- organized geometry sensing.
We investigated the simulation files provided by the authors and found that the model neither accounts for actual MinE membrane interactions nor for any observed MinDE protein patterns. A detailed discussion of our analysis can be found in the supplementary document hosted at arxiv.org/abs/1403.5934.


Letter on journal's website