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Monday, 28 June, 2010

Pulling a Single Polymer Molecule off a Substrate Reveals the Binding Thermodynamics of Cosolutes

M. Geisler, R. R. Netz, and T. Hugel -
Angew. Chem. Int. Edition, Vol. 49 (28), pp. 4730-4733 (2010)

To bind or not to bind: Cosolutes modify, or even determine, the interactions between macromolecules and surfaces. A combination of single-molecule atomic force microscopy with thermodynamic modeling allows the extraction of the binding parameters of cosolutes onto a macromolecule in solution and also in its surface-adsorbed state.


Article on journal's website