Monday, 18 July, 2011
pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica
A. Schlossbauer, C. Dohmen, D. Schaffert, E. Wagner, and T. Bein -
Angew. Chem. Int. Edition, Vol. 50 (30), pp. 6828-6830 (2011)
A pH-labile immobilization of the melittin peptide with acetal linkers in the pore system of a SBA-15 host allows release of the peptide upon decrease of the pH value from 7.4 to 5.5. Such a release is shown by melittin-induced lysis of mouse erythrocytes. The method could be used to prepare new silica-based peptide delivery systems for targeted cancer therapy.