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Thursday, 01 November, 2007

Finding the right spot to start transcription

P. Cramer -
Nature Struct. Mol. Biol. 14, 686 (2007)

How does RNA polymerase II cooperate with initiation factors to locate transcription start sites throughout the genome? A new cross-linking approach reveals previously unknown initiation factor–binding sites on the polymerase surface. The resulting model of the transcription initiation complex suggests that initiation factors cooperate above and inside the polymerase active center cleft to open DNA and find the transcription start site.

 

Article on journal's website