PhD student in the group of Prof. Hermann Gaub, LMU Munich
2007 - 2009
PhD student in the group of Prof. Roland Kersting, LMU Munich
2006 - 2007
Master thesis in the group of Professor Ifor D.W. Samuel
Topic of Master thesis: "single-molecule aggregation studies of amyloid
2006 - 2007
M.Sc. program in physics at the University of St Andrews, UK
Student assistant at Prof. Ludwig Schultz´ Group, IFW Dresden
2003 - 2006
Diploma in Physics at the LMU Munich
Student assistant at Prof. Kerstings Group, LMU Munich
Scholarship of the IDK-NBT (Elitenetwork of Bavaria)
Spatial isolation of the investigated molecules is a prerequisite of optical single-molecule experiments. Commonly this is done with dilution. With dilution, however, it is impossible to position the single-molecules relative to objects or secondary molecules whose influence might be of scientific interest. A novel bottom-up assembly method is Single-Molecule Cut-and-Paste (SMCP). Here single molecules are picked up from a depot and positioned in a previously empty target area with an AFM tip and the help of differentially coupled force anchors. Thus SMCP provides the ability to isolate single-molecules at designated positions with nanometer precision.
My research goal is to use SMCP to set up networks of different interacting enzymes in designed geometries. Thus the direct interaction of enzymes can be studied in a single-molecule like experiment.
This also involves the use of so called zero-mode-waveguides: Nanometric pores in aluminum films. These cavities drastically reduce the optical observation volume of a single-molecule experiment. This enables the use of labeled substrates at enzymatically relevant millimolar concentrations.
G. Acuna, S. F. Heucke, F. Kuchler, H. T. Chen, A. J. Taylor, and R. Kersting:
"Surface Plasmons in Terahertz Metamaterials"
Optics Express, Vol. 16, Issue 23, pp. 18745-18751 (2008)