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Stephan Heucke

Curriculum Vitae

since 2009

PhD student in the group of Prof. Hermann Gaub, LMU Munich

2007 - 2009

PhD student in the group of Prof. Roland Kersting, LMU Munich

2006 - 2007

Master thesis in the group of Professor Ifor D.W. Samuel

Topic of Master thesis: "single-molecule aggregation studies of amyloid
proteins by stepwise photobleaching"

2006 - 2007

M.Sc. program in physics at the University of St Andrews, UK

2006

Student assistant at Prof. Ludwig Schultz┬┤ Group, IFW Dresden

2003 - 2006

Diploma in Physics at the LMU Munich

2003

Student assistant at Prof. Kerstings Group, LMU Munich

 

Scholarships

since 2007

Scholarship of the IDK-NBT (Elitenetwork of Bavaria)

Lipid-Vesikel

Research project

Spatial isolation of the investigated molecules is a prerequisite of optical single-molecule experiments. Commonly this is done with dilution. With dilution, however, it is impossible to position the single-molecules relative to objects or secondary molecules whose influence might be of scientific interest. A novel bottom-up assembly method is Single-Molecule Cut-and-Paste (SMCP). Here single molecules are picked up from a depot and positioned in a previously empty target area with an AFM tip and the help of differentially coupled force anchors. Thus SMCP provides the ability to isolate single-molecules at designated positions with nanometer precision.

My research goal is to use SMCP to set up networks of different interacting enzymes in designed geometries. Thus the direct interaction of enzymes can be studied in a single-molecule like experiment.

This also involves the use of so called zero-mode-waveguides: Nanometric pores in aluminum films. These cavities drastically reduce the optical observation volume of a single-molecule experiment. This enables the use of  labeled substrates at enzymatically relevant millimolar concentrations.

watch smiley movie...

Publications

G. Acuna, S. F. Heucke, F. Kuchler, H. T. Chen, A. J. Taylor, and R. Kersting:
"Surface Plasmons in Terahertz Metamaterials"
Optics Express, Vol. 16, Issue 23, pp. 18745-18751 (2008)