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CeNS Center for NanoScience LMU Ludwig-Maximilians-Universität München
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Michael Lidschreiber

German

Curriculum Vitae

since 2008

PhD student in the group of Prof. Patrick Cramer, LMU Munich

2008

Master Sc. in biochemistry, LMU Munich Master Thesis in Joerg Nickelsen’s group at the LMU Munich “Protein sorting in Chlamydomonas reinhardtii.”

2007

Master of Sc. in Bioinformatics Master Thesis in Denis Shields’ group at the Conway Institute of Biomolecular & Biomedical Research (UCD, Dublin), in collaboration with Hans-Werner Mewes’ group at the Munich Information Center for Protein Sequences (MIPS-GSF), Neuherberg. “Genome-wide identification of short linear protein motifs”

2007

Research visit at the Conway Institute of Biomolecular & Biomedical Research (University College Dublin), as part of my bioinformatics master thesis project (Shields group)

2005 - 2008

Graduate student of Biochemistry (M.Sc.) and Bioinformatics (M.Sc.) at Technical University and LMU Munich

2002 - 2005

Bioinformatics undergraduate student (B.Sc.) at Technical University and LMU Munich Bachelor Thesis at the Munich Information Center for Protein Sequences (MIPS-GSF), Neuherberg (Frishman group). „Taxonomy-based protein secondary structure prediction.”

 

Scholarships

since 2008

Scholarship of the IDK-NBT (Elitenetwork of Bavaria)

since 2008

Student of the International Max-Planck Research School for Life Sciences (IMPRS-LS)

Research Project

The main underlying technique of my PhD project is immunoprecipitation of in vivo cross-linked chromatin coupled with DNA microarray hybridization (ChIP-on-chip). This method is used to determine in a genome-wide assay how proteins interact with DNA to regulate gene expression, and eventually influence cell growth, differentiation and aberrations in human disease. ChIP-on-chip experiments are highly interdisciplinary, as they require both, a profound knowledge of molecular biology techniques as well as the ability to implement and use computer algorithms for handling and interpretation of the massive amount of data generated by this high-throughput method.

The major part of my work will investigate protein factors which associate with RNA polymerase II during the elongation phase of gene transcription, in order to obtain a genome-wide picture of how, where, and when these individual factors are recruited to the transcription elongation complex.

Publications

A. Mayer, M. Lidschreiber, M. Siebert, K. Leike, J. Söding, P. Cramer:
"Uniform transitions of the general RNA polymerase II transcription complex."
Nature Struct. Mol. Biol. 17, 1272-1278 (2010)