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CeNS Center for NanoScience LMU Ludwig-Maximilians-Universität München
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Julia Blechinger

German

Curriculum Vitae

2009 - 2010

IDK Student Representative

since 2007

PhD student in the group of Prof. Christoph Bräuchle, LMU Munich

2007

Master thesis in the group of Prof. Christoph Bräuchle, LMU Munich

Master Thesis: functionalization of mesoporous systems
as highly selective method for the control of single molecule diffusion

2005 - 2007

Master of science in chemistry at the LMU Munich

2006 - 2006

Internship at the research group of Prof. P. Lincoln, Chalmers. University of Technology, Gothenburg, Sweden.

Research project: Intercalation of Ru(II) Complexes in DNA

 

Scholarships

since 2008

Scholarship of the IDK-NBT (Elitenetwork of Bavaria)

since 2007

e-fellows.net fellowship

Research Project

Due to a rising amount of nanoparticles (NPs) in the environment leading to a constant exposure of the human body, NP uptake via our airways system, gastro-intestinal tract and skin is unavoidable. As NPs are able to penetrate physiological barriers they enter our blood and lymphatic vessel system which is covered by endothelial cells (ECs). These cells sense all intravascular physiological and artificial components. Moreover they play an essential role in controlling inflammation, coagulation, blood flow and blood pressure. Hence it is crucial to know the precise effect of NPs on these cells.

In my PhD project the effect of various kinds of industrial relevant NPs (e.g. Au, Ag, Pt) on living ECs will be studied by fluorescence microscopy and single NP tracking. These techniques allow to monitor the uptake of single NPs in living cells and to investigate the interaction with specific cell components. To mimic in vivo conditions this technique will be combined with a microfluidic system allowing to establish a blood flow like microfluidic flow on top of the ECs. Moreover the bioactivity of the ECs will be studied simultaneously by sophisticated essays. The project is funded by the DFG priority program (SPP 1313) “Bio-Nano-Responses”. The experiments will be done in collaboration with the groups of Prof. A. Reller (synthesis and characterization of nanoparticles), Prof. A. Wixforth and Dr. M. F. Schneider (Lab on a Chip systems, micro and nanofluidics) and PD Dr. S. W. Schneider (endothelial cell biology).

Publications

J. Blechinger, R. Herrmann, D. Kiener, F. J. García-García, C. Scheu, A. Reller, C. Bräuchle:
"Perylene-Labeled Silica Nanoparticles: Synthesis and Characterization of Three Novel
Silica Nanoparticle Species for Live-Cell Imaging"
first published online: 27 SEP 2010 small 2010

T. Lebold, L.A. Mühlstein, J. Blechinger, M. Riederer, H. Amenitsch, R. Köhn, K. Peneva, K. Müllen, J. Michaelis, C. Bräuchle, and T. Bein:
"Tuning single-molecule dynamics in functionalized mesoporous silica"
Chem. Eur. J. 15, 1661-167 (2009)

F. Westerlund, P. Nordell, J. Blechinger, T.M. Santos, B. Norden, and P. Lincoln:
"Complex DNA binding kinetics resolved-by combined circular dichroism and luminescence analysis"
Journal of Physical Chemistry B, 112(21): p. 6688-6694 (2008)