Garwin Pichler
German
Curriculum Vitae
since 2008 | PhD student in the group of |
2006 - 2008 | Master of Science in Biochemistry, LMU Munich |
2008 | Master Thesis: “Early events in cell polarization in S. cerevisiae”; Cellular Dynamics and Cell patterning, in the group of Dr. Roland Wedlich-Söldner, MPI Martinsried |
2006 | Bachelor Thesis: „ Expression and purification of INO80-complex subunits of S. cerevisiae”, Structural biology of DNA repair machines, Prof. Dr. Karl-Peter Hopfner, Gene Center, LMU Munich |
2003 - 2006 | Bachelors of Science in Chemistry and Biochemistry |
Prof. Heinrich Leonhardt
Scholarships
since 2008 | Scholarship of the IDK-NBT (Elitenetwork of Bavaria) |
since 2008 | International Max Planck Research School (IMPRS) |
Research Project
DNA methylation plays a central role in the regulation of genome activity and stability. We have previously characterized functional domains of the major DNA methyltransferase (Dnmt1) and will now focus on the molecular mechanism of its maintenance activity. The main goal of my PhD thesis would be to purify and characterize defined subdomains and mutants of the major DNA methyltransferase (Dnmt1) and solve the structure through crystallography. In a combination of crystallography, Cryo-EM and bioinformatic analyses it would be possible to stepwise assemble the structure of Dnmt1 and its complexes with DNA. These structural and functional data should elucidate the molecular basis of the stable inheritance of epigenetic information.
pichler
biologie.uni-muenchen.de