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Farzad Sekhavati

Iranian

Curriculum Vitae 

Since 2011

PhD student in the group of Prof. Joachim Rädler, LMU Munich

2010 - 2011

PhD student in the group of Dr. Alexander Gigler, LMU Munich

2009 – 2010

MSc. Erasmus Mundus Nanoscience and Nanotechnology, Delft University of Technology (TUD), Delft, Netherlands

2008 - 2009

MSc. Erasmus Mundus Nanoscience and Nanotechnology, Chalmers University of Technology (CTH), Gothenburg, Sweden

Master Thesis: “E-Coli properties under pressure in microchannel”

2005 - 2008

Double Major in Physics,  Amirkabir Univeristy of Technology (AUT), Tehran

Thesis title: “Quantitative study of nanopores arrangement in alumina membrane using Furrier transform analysis

2003 – 2008

BSc. Mechanical Engineering, Amirkabir Univeristy of Technology (AUT), Tehran, Iran

Bachelor Thesis: “Design and characterization of a micromotor for swimming microrobot”

 

Scholarships

Since 2010

Scholarship of the IDK-NBT (Elite Network of Bavaria)

2008 - 2010

Erasmus Mundus master scholarship

Research Project

In this project, we are developing a microstructured platform to trap non-adherent cells in a small volume. The microstructure is made of PEG-DA or PDMS which are proven to be non-toxic to the cells. The device geometry and surface properties are optimized for long-term observation of stem-cell development and differentiation. We concluded that micro-trenches with width of 15-20 µm and length of 80 µm can are suitable for the observation up to two generations.
The model cell line is MEL (Mouse erythroleukemia) cells with some similar physical properties to stem-cells. Phase-contrast microscopy and fluorescent microscopy are used as two imaging techniques for long-term observation. In the project we expect to observe the differentiation of stem-cell after second generation and be able to track down the mother cell. The parallel observation in large quantity of single cell compartment enables us to get statistically relevant data to be able to describe the stochastic phenomenon of stem-cell differentiation. Next step would be to continue the experiment for several more generations and build the differentiation tree of each stem-cell.

Publications

J. Männik, F. Sekhavati, J. E. Keymer and C. Dekker:
“Bacteria in submicron channels and microvalves”,
Proc 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 3-7 October 2010, p 1376-1378.