Dorothee Schupp

Curriculum Vitae

since 2007	PhD student in the group of Prof. Christoph Bräuchle, LMU Munich
2006 - 2007	Diploma thesis “Analyse von endokrin wirksamen Substanzen mit optischen Sensoren” in the group of Prof. Gauglitz, Institute for Physical Chemistry, Eberhard-Karls Universität Tübingen
2004 - 2005	Studies abroad at Ecole Nationale Supérieure de Chimie de Lille, France
2002 - 2007	Studies of chemistry at Eberhard-Karls Universität Tübingen

Scholarships

since 2007	Scholarship of the IDK-NBT (Elitenetwork of Bavaria)
since 2005	e-fellows.net fellowship
2004 / 2005	Baden-Württemberg fellowship, Landesstiftung Baden-Württemberg

Research project

My research focuses on the entry pathways of Herpes simplex virus (HSV-1). Herpes is a latent disease, more than 90% of the population are considered to be carriers of the virus. Neither an effective medication nor a potent vaccination is available yet.
By means of single virus tracing – a method developed in the group of Prof. Bräuchle – I will study the entry of HSV in different cell lines in real time within a group of researchers. The observation of the entry of single virus particles in living cells and their intracellular transport requires highly sensitive microscopial techniques. This project is conducted in close collaboration with Prof. Sodeik of the Hannover Medical School.
It has been described that the entry pathways of this virions are cell type dependent. Two general pathways are implicated in HSV-1 entry: via direct fusion with the plasma membrane or endocytosis followed by fusion with a neutral as well as an acidic endosome.
In my project I will investigate those processes in detail in terms of internalization, intracellular transport as well as cell-to-cell spread of the virus particles.

dorothee.schuppcup.uni-muenchen.de