PhD student in the group of Prof. Dr. Thomas Bein, LMU Munich
Internship at the Research group of Dr. Stefano Leporatti. National Nanotechnology Lab CNR- Nano. University of Salento- Lecce, Italy
Topic of Master Thesis: "Validation of drug nanocolloids and polyelectrolyte capsules as novel carriers for controlled drug delivery into ovarian cancer cells"
2008 - 2010
Master Degree in Medical Biotechnology and Molecular Medicine. Faculty of Biotechnology. University of Bari, Italy
Internship at the Research group of Dr. Carlo Marobbio. Pharmaceutical Biological Department. Faculty of Pharmacy- University of Bari, Italy
2005 - 2008
Bachelor Degree in Healthcare and Pharmaceutical Biotechnology. Faculty of Biotechnology. University of Bari- Bari, Italy
Topic of Bachelor Thesis: "L. Pneumophila Lpp2981 gene cloning and expression in S. Cerevisae"
Scholarship of the IDK-NBT (Elite Network of Bavaria)
NanoBioTechnologv is one of the most promising Nanotechnology fields and its tools could improve significantly current clinical- biological practice, thus leading to much more specific diseases treatments in the next future. In this scenario, lots of efforts about nanoparticles setting up as drug delivery systems are made. In my PhD project I want to study Supported Lipid Bilayer (SLB) coating of Silica Nanoparticles in order to create a smart drug delivery tool. SLB- Silica nanoparticles will be supposed to release inner cargo upon exogenous stimuli as a trigger, in order to optimize drug release at target site and, at the same time, avoid unwanted premature drug release effects. SLB Surface functionalization approaches will also be established, in order to increase Silica Nanocarriers specificity towards cell lines/tissues of interest.
D. Vergara, C. Bellomo, X. Zhang, V. Vergaro, A. Tinelli, V. Lorusso, R. Rinaldi, YM. Lvov, S. Leporatti, M. Maffia:
"Lapatinib/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancer."
Nanomedicine. 2011 Nov 16. [Epub ahead of print]
V. Vergaro, F. Scarlino, C. Bellomo, R. Rinaldi, D. Vergara, M. Maffia, F. Baldassarre, G. Giannelli, X. Zhang, YM. Lvov, S. Leporatti:
"Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells."
Adv Drug Deliv Rev. 2011 Aug 14;63(9):847-64. Epub 2011 May 18