Single-Molecule Fluorescence Spectroscopy on DNA origami
Prof. Philip Tinnefeld, Ludwig-Maximilians-University Munich (LMU)
Project:
The formation of DNA nanostructures is commonly studied using gel electrophoresis, atomic force microscopy and transmission electron microscopy. In this project, we will use superresolution fluorescence microscopy and single-molecule fluorescence resonance energy transfer (FRET) to study the formation and function of new kinds of structures and functionalities obtained with the scaffolded DNA-origami technique. DNA origami represent fully addressable molecular breadboards that will be used for 3D-nanoscale rulers for superresolution microscopy and will allow the construction of programmable energy transfer networks.
Information about the research group:
http://www.biophysik.physik.uni-muenchen.de/

