Prof. Tim Liedl, Department of Physics, Ludwig-Maximilians-University Munich (LMU)

Project:
In this project, we want to design DNA nanostructures [1] that interact with living cells. Immune cells, for example, can be stimulated with short DNA sequences known as Cytosine-phosphate-Guanin (CpG) motifs [2]. A systematic study of the immunostimulatory potential of precisely positioned CpGs could shed light on immunological cellular responses.

Required Skills:
The applicant should hold a master in Physics or Biochemistry. She or he ideally has acquired knowledge in self assembly processes, operation of TIRF, atomic force or electrone microscopes and is able to develop her or his own PhD project.


1. P. W. K. Rothemund, Folding DNA to create nanoscale shapes and patterns, Nature, 440, 297-302 (2006)
2. V. J. Schüller et al.,Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures, ACS Nano, doi: 10.1021/nn203161y (2011)

More information about the group:
Prof. Liedl's website