Prof. Tim Liedl, Department for Physics, Ludwig-Maximilians-Universität München (LMU)

Project:
Self-assembling cages built from DNA should be designed and manufactured using the DNA origami method. To achieve mechanically stable and bio-responsive cages, building principles of tensegrity and triangulation should be applied. DNA cages which are responsive to biological signals such as mRNA, DNAzames or endonucleases could be of enormous interest for drug delivery applications and may serve as model systems to help to understand fundamental processes of cell dynamics and mechanotransduction.

The applicant should have expertise in:

• Single-molecule fluorescence imaging
• DNA self assembly
• Surface functionalization (polymer coating, SLB preparation, flow cells ...)
• Sound wet lab experience (gel electrophoresis, PCR, buffer preparation ...)
• MATLAB programming

Information about the research group:

http://www.softmatter.physik.uni-muenchen.de/tiki-index.php