Prof. Don Lamb, Department of Chemistry, Ludwig-Maximilians-University Munich (LMU)

Project:
Proteins are dynamic machines that perform the functions of life. Using single molecule methods, in particular, single-pair Förster Resonance Energy Transfer and Fluorescence Correlation Spectroscopy, we are obtaining unprecedented insight into how these machines fold and function. Using a biophysical approach, we maximize the information we can gain from experiments on individual proteins to understand these fascinating machines. The focus of this PhD project is the functioning of the proteasome 26S, the protein responsible for digesting malfunctioning and misfolded proteins and instrumental in maintaining cellular health. With the advanced fluorescence methods available in our group, we will quantify the stability, stoichiometry and dynamics of protease complexes. We are looking for exceptionally talented and motivated people interested in working on challenging projects in an interdisciplinary research area.

More information about the group:
Prof. Lamb's website