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PhD Position – Single Molecule Mechano-Enzymatics

A position in the field of biochemistry/biotechnology will be available in 2014.

Project: We pick individual enzymes with an AFM-tip and place them in the cavity of a zero mode waveguide. We apply force and control their conformation while in parallel the turnover is measured by single molecule fluorescence. This combination of force spectroscopy and high resolution fluorescence microscopy provides a unique and novel insight in the molecular mechanisms of force sensing proteins. A detailed analysis of the mechano-enzymatics of Titin Kinase will be the main focus; other enzymes like Dicer and FAK will be investigated as model systems.

Requirements: A  profound biochemistry education is required, know how in protein engineering/modification is desirable.

Group: Prof. Hermann Gaub, Department of Physics, LMU Munich

Prof. Gaub's website